Pain and Inflammation
From cells to organ systems, the human body is intricate, complex and reactive. Because it is such an interconnected system, no single cell or body part functions independently. It's a system built on responses and inter-relationships designed to maintain balance within the systemic whole. The immune system is a key component and is essential to homeostasis and survival.
When a body becomes inflamed, the immune system is called upon to repair and heal damaged tissue or to battle against unwanted invaders like viruses and bacteria. While it is true that inflammation can effectively trigger a critical immune response, it is also true that inflammation can wage a savage war within our bodies. By looking at the negative power of inflammation’s destructive force, we begin to uncover the roots of the most feared modern diseases.
We begin your journey with a theory, one that has shifted our previous view that inflammation is an essential and supportive response to disease, illness and injury.
While we search to solve the mysteries of disease, our observational studies and laboratory research exposed one unifier, one common factor, inflammation.
There are generally two types of inflammation
Acute inflammation erupts quickly and subsides within a few days or in rare cases it can linger for weeks. Things like allergies, poor diet, colds, bacteria, injury, or cuts can trigger acute inflammation, and acute inflammation can spark diseases like bronchitis. It is logical that chronic inflammation traditionally lasts for a much longer time than its acute cousin, enabling chronic inflammation to foster long term, unwanted physical problems. It is usually the body's failure to subdue acute inflammation within a reasonable span of time that stimulates its morphing into chronic inflammation.
A Nation of Inflammation
Even though pro-inflammatory processes are stimulated naturally, inflammation is a redundant component of dire diseases. When the inflammatory response is prolonged or occurs in areas where it is not needed, inflammatory disease states will develop and may cause increasing pain. The World Health Organization (WHO) ranks diseases that form as a result of chronic inflammation as the most significant causes of death. It is important to emphasize the power of the threat to health that chronic inflammation poses. (1)
The WHO reported that nearly 125 million Americans are living with a chronic condition, 61 million of which have more than one. The occurrences of diseases associated with chronic inflammation is anticipated to increase at an alarming pace over the next 30 years in the United States. Estimates conducted by the Rand Corporation in 2014 showed that nearly 60% of Americans had at least one chronic condition, 42% had more than one and 12% of adults had 5 or more chronic conditions. (1)
Chronic inflammatory diseases like stroke, chronic respiratory diseases, heart disorders, cancer, obesity, and diabetes account for the death of 3 out of 5 people, worldwide.
Inflammation Related Statistics
Diabetes: Diabetes is the 7th leading cause of death in the US. In 2015, The American Diabetes Association reported that 30.3 million people or 9.4% of the population in the United States had diabetes. (1) It is more than shocking to know that more than 84 million US adults. This equates to over 1/3 of the population being pre-diabetic and 90% unaware that they are.
Cardiovascular Diseases: The American Heart Association, in an updated report from 2017 stated that cardiovascular diseases accounted for 1 out of every three deaths or approximately 800,000 deaths annually in the United States. (1) Coronary heart disease, stroke and heart failure account for 1 out of 20 deaths in the US. Globally, cardiovascular disease is responsible for 31% of all deaths. (1)
Arthritis and Joint Diseases: 350 million people worldwide and nearly 54 million people in the United States (20% of the population) suffer from arthritis and joint disease. This number is expected to exceed 78 million people by 2040. Rheumatoid arthritis adds an additional 2.1 million Americans. (1)
Allergies: The sixth largest incidence of chronic disease in the United States is associated with allergies. Fifty (50) million Americans are diagnosed each year. Not surprisingly, asthma affects more than 24 million people in the United States and that includes 6 million children. (1)Chronic Obstructive Pulmonary Disease (COPD): COPD is the third most common cause of death in the United States. Nearly 15.7 million Americans (6.4%) were reported to have been diagnosed with COPD in 2017, however The American Lung Association estimates that number may closer to 24 million adults living with COPD.
Cannabinoids Broad Solutions to Pain
The technical complexities of the human body and all its systems is stunning. One could spend a lifetime reviewing observational studies and laboratory research without making a dent.
With well-regarded scientific studies confirming the effectiveness of cannabinoids against inflammation and disease, there is a solid basis to promote the supplementation and use of cannabinoids to fight against disease and ameliorate compromised health issues. The following provides key research on inflammation and describes the value in the supplemental use of full spectrum hemp oil in controlling inflammation.
CB1 & CB2 Receptors
Both CB1 and CB2 receptors have been found on immune cells. This suggests that cannabinoids play an important role in regulating the immune system. In some models, cannabinoids downregulate proteins that are important in “signaling cells” to initiate the inflammatory process (Cytokine and Chemokine). In other models, cannabinoids upregulate cells as a mechanism to suppress inflammatory responses (T-regulatory or Tregs). (2)
CBD and CBG have been shown to be potent antidotes to inflammatory disorders, especially when the disorder is triggered by activated T-cells or other cellular immuno components. The use of these cannabinoids such has led to immunosuppression and recovery from immune-mediated injury to organs, like the liver. (3)
The number one reason people turn to CBD oil is to relieve pain and inflammation. (4) CBD, CBG, CBN and other non-intoxicating cannabinoids found in hemp oil have proven, in a variety of clinical settings, to be effective therapeutic agents. (9)
Analgesics and anti-inflammatory drugs traditionally used to treat chronic pain, including neuropathic pain, deliver questionable relief, may invite addiction and can deliver highly adverse side effects such as acute bleeding or even cardiac arrest. (5) There is strong evidence supporting the use of cannabinoids to alleviate chronic inflammatory and neuropathic pain without negative side effects. (6)
Specialized nerve endings called nociceptors evoke muscle pain. Hyperexcitability of the nociceptors result in higher levels of pain. (10) CBD and other cannabinoids that are naturally present in hemp oil have been shown to significantly reduce these excitatory impulses to the nociceptors, thereby reducing and/or eliminating pain within these tissues.(11)
Pain VS an Entourage of Cannabis Compounds
Cannabinoids like CBD are effective antidotes to inflammation. The full power of this plants ability to combat pain and inflammation comes from the vibrant combination of both cannabinoids and the less discussed terpenes that also reside within the hemp plant. Terpenes: a-pinene, beta caryophyllene, bisabolol, boswellic acid, d-limonene, guaiol, humulene, myrcene, limonene, ocimene, pseudopterosin, and tenuifolins contribute to calming inflammation and mediating pain within the muscles and the entire body.
As is now well known, it is the dynamic combination of cannabinoids, terpenes and flavonoids that produces the “entourage effect”, a powerhouse of healing compounds, all working together to dramatically reduce inflammation and eradicate pain in the muscles and restore balance to the body. (12)
Cannabinoid rich hemp oil is adaptive and can also work in synergy with terpenes that are not derived from hemp. Menthol is derived from various mints, but it’s a powerful terpene with proven synergetic properties. When menthol is added to topical pain formulations that include a full spectrum of cannabinoids, as well as hemp derived terpenes and flavonoids, the result is a more potent analgesic and anti-inflammatory treatment. Because menthol boosts absorption, it invites efficient penetration through the skin for faster delivery to the pain site for relief with expanded potency to the muscles or throughout the body.(13)
Innovative delivery systems of cannabinoids can activate rapid pain relief at its origins in the brain. If certain terpenes are inhaled, they can instantaneously stimulate nucleus accumbens, essentially “taking the edge off “of pain where it starts, in the brain.(8)
Cannflavins are phyto-nutrient flavonoids exclusive to hemp. Full spectrum hemp retains its natural cannflavins during processing. Cannflavin A has been found to reduce inflammation by inhibiting the inflammatory molecule PGE-2, just the way aspirin does, but cannflavin A does it more than 30 times more effectively, without any negative side effects.(14) TRPV1 receptors, such as the vanilloid receptor, contribute to non-addictive forms of pain relief. Glycine receptors (GlyRs), specifically the α3 GlyRs, directly suppress pain not only within the central nervous system but also in the ventral tegmental area of the midbrain, the amygdala, the hippocampus and the spinal cord without creating analgesic tolerance. (7)
It is the broad somatic reach without the need for increased doses that is believed to be the main reason why researchers found CBD and related cannabinoids as potential treatments for managing pain associated with spastic episodes in multiple sclerosis and the side effects of chemotherapy. (8)
While studies do tend to focus on CB1 & CB2 receptors throughout the brain and body, recent research is demonstrating that cannabinoids, do in fact bind to the less studied receptors in the endocannabinoid system.
The #1 Reason People Try Hemp
While powerful pharmaceuticals and over-the-counter products exist to decrease inflammation and reduce pain, or GI distress, they carry potentially devastating side effects and can contribute to the onset of chronic disease.(15) Pharmaceutical drugs are designed to produce a specific reaction and its “side or adverse effects” are traded as a “risk” against the “benefit” of the primary effect.
Symptom relief is only one piece of the therapeutic value of medicinal plants. Contrary to pharma medications, alternative plant therapies are directed towards aiding the body’s own healing process, acting gently to bring the systems and processes that have become deficient back into balance and helping to remove problematic excesses.
Interestingly, although not patentable by Big Pharma, raw extracts or in-tact plant materials are often more effective than their synthetic derivatives, as prescription drugs isolate and extract individual molecules from the benefits of the whole.
The anti-inflammatory properties of hemp and cannabis have been highly researched, and their benefits have become well known. The importance of reducing inflammatory responses becomes clear as we understand more about inflammation’s negative role. Initially, inflammation invites a needed healing response from the immune system, but it can also progress to chronic inflammation and instigate the onset of killer diseases and activate unrelenting pain.
Inflammation not only can shorten life; it can greatly diminish the quality of life. Sleep disorders relate to nearly every condition related to chronic pain. Most pain a person may experience, either short term or long term, comes as a direct result of inflammation. The most dreaded diseases can result from prolonged and chronic inflammation.
PAIN MANAGEMENT PRODUCTS
Suggested Complimentary Products
One World Live Pain Roller
OWL Pain Roller is a topical, full-spectrum CBD oil enhanced with terpenes. The Pain Roller is a standardized, lab-tested cannabidiol extract with 600 milligrams of CBD and powerful terpene actives. OWL Pain Roller has been designed to work by reducing physical pain and inflammation as soon as it's applied to the affected area.