Article References


1. Sleep Statistics - Data About Sleep and Sleep Disorders. (2018). American Sleep Association. Retrieved 5 June 2019, from sleep/sleep-statistics/ 

2. What Are the Most Common Types of Sleep Disorders? (2019). Verywell Health. Retrieved 7 June 2019, from

3. Cannabis & Sleep Disturbances | Project CBD. (2019). Retrieved 7 June 2019, from

4. Vaughn LK, Denning G, Stuhr KL, de Wit H, Hill MN, Hillard CJ. Endocannabinoid signalling: has it got rhythm? Br J Pharmacol. 2010;160(3):530–543. doi:10.1111/j.1476- 5381.2010.00790.x  

5. Sleeping Pills Could Shorten Your Life: Chapter 1 of The Dark Side of Sleeping Pills, an ebook by Daniel F. Kripke, M.D. (2019). Retrieved 7 June 2019, from

6. What is the Role of the Endocannabinoid System in the Human Body? CBD Oil & Sleep Disorders. (2019). Retrieved 7 June 2019, from rid=573323

7. Parmet, S. (2019). Synthetic cannabinoid reduces sleep apnea | UIC Today. Retrieved 7 June 2019, from reduces-sleep-apnea

8. How to interpret the CBD & THC ratio results? (2019). Cannabis Test Alpha-CAT. Retrieved 7 June 2019, from interpret-the-cbd-thc-ratios/

9. Apothecarium. (2018c, August 3). Cannabinoid 101: CBN [Blog post]. Retrieved April 21, 2019, from

10. Anand P, Whiteside G, Fowler CJ, Hohmann AG. Targeting CB2 receptors and the endocannabinoid system for the treatment of pain. Brain Res Rev. 2009;60(1):255– 266. doi: 10.1016/j.brainresrev.2008.12.003



1.  Facts & Statistics | Anxiety and Depression Association of America, ADAA. (2019). Retrieved 19 May 2019, from room/facts-statistics

2. What are the Most Common Reasons People Take CBD? (Why People Use CBD) - CBD School. (2019). CBD School. Retrieved 19 May 2019, from

3. Russo EB, Burnett A, Hall B, Parker KK. Agonistic properties of cannabidiol at 5- HT1a receptors. Neurochem Res. 2005;30:1037–1043. doi: 10.1007/s11064-005-6978-1.

4. McPartland JM, Russo EB. Cannabis and cannabis extracts: greater than the sum of their parts? J Cannabis Therap. 2001b;1:103–132.

5. Soares VP, Campos AC. Evidences for the Anti-panic Actions of Cannabidiol. Curr Neuropharmacol. 2017;15(2):291–299. doi:10.2174/1570159X14666160509123955

6. Manseau, M.W. & Goff, D.C. Neurotherapeutics (2015) 12: 816.

7. Tambaro S, Bortolato M. Cannabinoid- related agents in the treatment of anxiety disorders: current knowledge and future perspectives. Recent Pat CNS Drug Discov. 2012;7(1):25–40.



1. Schicho R, Storr M. Alternative targets within the endocannabinoid system for future treatment of gastrointestinal diseases. Can J Gastroenterol. 2011;25(7):377–383.

2. Vagus Nerve Stimulation a New Approach in the Treatment of Crohn's Disease - Full Text View - (2019). Retrieved 17 May 2019, from

3. Ali T. Sleep and Inflammatory Bowel Disease. Gastroenterol Hepatol (N Y). 2014;10(11):748–751.



1. Pahwa R, Jialal I. Chronic Inflammation. [Updated 2018 Oct 27]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2019 Jan-. Available from: 73/

2. Eisenstein TK, Meissler JJ. Effects of Cannabinoids on T-cell Function and Resistance to Infection. J Neuroimmune Pharmacol. 2015;10(2):204–216. doi:10.1007/s11481-015-9603-3

3. Nagarkatti P, Pandey R, Rieder SA, Hegde VL, Nagarkatti M. Cannabinoids as novel anti- inflammatory drugs. Future Med Chem. 2009;1(7):1333–1349. doi:10.4155/fmc.09.93

4. Wilson,D, C. (2018). CBD oil for pain management: Effects, benefits, and uses. Medical News Today. Retrieved 16 May 2019, from 19475.php

5. Lynch ME, Watson CP. The pharmacotherapy of chronic pain: a review. Pain Res Manag.2006;11(1):11–38.

6. Maroon J, Bost J. Review of the neurological benefits of phytocannabinoids. Surg Neurol Int. 2018;9:91. Published 2018 Apr 26. doi:10.4103/sni.sni_45_18

7. Ibeas Bih C, Chen T, Nunn AV, Bazelot M, Dallas M, Whalley BJ. Molecular Targets of Cannabidiol in Neurological Disorders. Neurotherapeutics. 2015;12(4):699–730. doi:10.1007/s13311-015-0377-3

8. Kogan NM, Mechoulam R. Cannabinoids in health and disease.Dialogues Clin Neurosci.2007;9(4):413–430.

9. Elikkottil J, Gupta P, Gupta K. The analgesic potential of cannabinoids [published correction appears in J Opioid Manag. 2010 Jan-Feb;6(1):14. Elikottil, Jaseena [corrected to Elikkottil, Jaseena. J Opioid Manag.2009;5(6):341–357.

10. Dubin,Patapoutian.Nociceptors:the sensors of the pain pathway.JClinInvest. 2010;120(11):3760–3772. doi:10.1172/JCI42843

11. GoldMS,GebhartGF.Nociceptor sensitization in pain pathogenesis.NatMed. 2010; 16(11):1248–1257.doi:10.1038/nm.2235

12. EP,B.(2019).Medicinal Properties of Cannabinoids,Terpenes,and Flavonoids in Cannabis,and Benefits in Migraine, Headache, and Pain: An Update on Current Evidence -PubMed NCBI. May 2019, from 161

13. Terpene-anoverview|ScienceDirectTopics (2019). Retrieved 16May2019,from ology-toxicology-and-pharmaceutical- science/terpene

14. Russo EB. Cannabinoids in the management of difficult to treat pain.Ther Clin Risk Manag.2008;4(1):245–259.

15. How NSAIDs Destroy Your Body. (2019). Dr. Axe. Retrieved 17 May 2019, from



1. Diet & the Endocannabinoid System: Food for Thought | Project CBD. (2019). Retrieved 10 June 2019, from

2. Jadoon KA, Tan GD, O'Sullivan SE. A single dose of cannabidiol reduces blood pressure in healthy volunteers in a randomized crossover study. JCI Insight. 2017;2(12):e93760. Published 2017 Jun 15. doi:10.1172/jci.insight.937



1. Alzheimer's Disease Fact Sheet Alzheimer's Disease Fact Sheet. (2020). Retrieved 22 January 2020, from

2. Gemma C, Vila J, Bachstetter A, et al. Oxidative Stress and the Aging Brain: From Theory to Prevention. In: Riddle DR, editor. Brain Aging: Models, Methods, and Mechanisms. Boca Raton (FL): CRC Press/Taylor & Francis; 2007. Chapter 15. Available from:

3. CBD, Alzheimer’s and More. (2020). Retrieved 22 January 2020, from

4. Ferreira FF, Ribeiro FF, Rodrigues RS, Sebastião AM, Xapelli S. Brain-Derived Neurotrophic Factor (BDNF) Role in Cannabinoid-Mediated Neurogenesis. Front Cell Neurosci. 2018;12:441. Published 2018 Nov 28. doi:10.3389/fncel.2018.00441

5. CBD as Preventative Medicine | Project CBD. (2019). Retrieved 23 May 2019, from